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Chronic Myelocytic Leukaemia Presenting in Blastic Transformation: Two Cases Primarily Diagnosed as Acute Myelocytic Leukaemia
Author(s) -
Worm AnneMarie,
PedersenBjergaard Jens
Publication year - 1977
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1977.tb01198.x
Subject(s) - myelocytic leukemia , medicine , chronic myeloid leukaemia , myeloid leukaemia , philadelphia chromosome , childhood leukaemia , leukemia , pediatrics , chromosomal translocation , biochemistry , gene , chemistry
The interval from diagnosis of chronic myelocytic leukaemia (CML) to onset of blastic transformation (BT) can vary from days to several years. This blastic phase of CML is indistinguishable from acute myelocytic leukaemia (AML), both clinically and morphologically. The Ph 1 chromosome has occasionally been demonstrated in acute leukaemia and it has been suggested that these cases may represent CML presenting in BT. 2 such patients are reported, in 1 of whom the characteristics after treatment further confirmed the diagnosis of CML. Differentiation between CML presenting in BT and AML has both prognostic and therapeutic value. For this reason it is recommended that cytogenetic screening for the Ph 1 chromosome should be included in the initial examination of patients with acute leukaemia.