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Atypical Intraerythrocytic Pyruvate Kinase in some Haematological Diseases
Author(s) -
Hanel H. K.,
Philip P.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb02839.x
Subject(s) - polycythaemia , pyruvate kinase , haemolysis , pyruvate kinase deficiency , myelofibrosis , polycythemia vera , medicine , biology , immunology , biochemistry , enzyme , glycolysis , bone marrow
An atypical pyruvate kinase (PK) in erythrocytes was studied in a family with several different haematological diseases: non‐spherocytic haemolysis, thrombocytopenia, myelofibrosis and polycythaemic traits. Atypical intraerythrocytic PK was also found in a group of non‐related patients with myelofibrosis and polycythaemia vera. The atypical PK was characterised by abnormal urea inhibition and other relevant biochemical parameters.