Premium
Chromosome Banding Studies in Philadelphia Chromosome Positive Myeloid Leukaemia
Author(s) -
Lawler Sylvia D.,
O'Malley Frances,
Lobb D. S.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb02836.x
Subject(s) - isochromosome , chromosomal translocation , dicentric chromosome , biology , karyotype , chromosome , genetics , myeloid , breakpoint cluster region , microbiology and biotechnology , cancer research , gene
A cytogenetic study of Ph 1 positive myeloid leukaemia in both chronic and acute phases had been made by a chromosome banding technique. The translocation {t(9;22) (q34;q11)}, designated t(Ph 1 ) was present in the myeloid cells of 43 of 44 patients; the exceptional case had normal number 9 chromosomes and a different translocation {t(19;22) (q13;q11)}. A translocation additional to that involving the Ph 1 was found as a stable abnormality present in all myeloid cells in 4 patients, chromosome 17 being involved in 2. The association of isochromosome number 17 with blast crisis was confirmed. New data were obtained concerning the significance of duplicated or dicentric Ph 1 chromosomes and their relationship with the 9q + anomaly. Monoclonal origin of Ph 1 was confirmed in cases with polymorphic number 22 or 9 chromosomes.