Premium
Membrane Bound IgG on Erythroblasts in Pure Red Cell Aplasia following Thymectomy
Author(s) -
Björkholm M.,
Holm G.,
Mellstedt H.,
Carlberger G.,
Nisell J.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01444.x
Subject(s) - pure red cell aplasia , thymectomy , cyclophosphamide , medicine , autoantibody , aplasia , antibody , bone marrow , immunology , red cell , clearance , immunofluorescence , lymphocyte , myasthenia gravis , chemotherapy , urology
A case of pure red cell aplasia appearing 6 months following thymectomy is reported in a 43‐year‐old man. Immunofluorescence studies of the patient's bone marrow have demonstrated the presence of membrane‐bound IgG on the majority of erythroblasts and some mature erythrocytes. It is suggested that the IgG represents anti‐erythroid autoantibodies. The number of Ig‐bearing lymphocytes in peripheral blood was decreased as was the level of immunoglobulins indicating a B‐lymphocyte deficiency. T‐lymphocyte functions were without remarks. The patient was initially treated with corticosteroids and oxymetholone. He responded well to this therapy but relapsed 9 month later. Cyclophosphamide treatment was started and followed by a complete haematologic remission.