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Abnormal Lymphocyte Populations in Pure Red Cell Aplasia
Author(s) -
FRØLAND STIG S.,
WISLØFF FINN,
STAVEM PER
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01181.x
Subject(s) - pure red cell aplasia , aplasia , lymphocyte , immunology , medicine , biology , bone marrow
Studies of blood lymphocytes from 4 patients with pure red cell aplasia were performed with lymphocyte surface markers, and with various in vitro tests for lymphocyte functions. Pathologically low B‐lymphocyte values were found. In contrast, no marked deviation from normals were seen for T‐lymphocytes and Fc‐receptor‐bearing lymphocytes thought largely to represent non‐B, non‐T‐lymphocytes. In 3 patients normal lymphocyte transformation was found with unspecific and specific mitogens, while the DNA‐synthesis induced by unspecific mitogens was subnormal in the fourth patient. The lymphocyte‐mediated PHA‐induced cytotoxicity against target cells in vitro was subnormal in 2 patients, while no depression was seen in antibody‐dependent cytotoxicity mediated in vitro by lymphocytes (K‐cells). It is concluded that considerable immunological abnormalities are associated with pure red cell aplasia, and the possible significance of this is discussed.