Premium
The Peripheral Platelet Count in Response to Intravenous Infusion of Isoprenaline
Author(s) -
OLSSON LARSBERTIL,
FREDÉN KRISTER,
KUTTI JACK,
LUNDBORG PER
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01177.x
Subject(s) - isoprenaline , platelet , epinephrine , peripheral , medicine , peripheral blood , endocrinology , spleen , anesthesia , stimulation
5 healthy male volunteers received i.v. infusions of isoprenaline in doses of 0.03, 0.06 and 0.09 μg × kg −1 × min −1 over a period of 6 min. A statistically significant decrease in the peripheral platelet count was obtained, but no dose‐response‐curve for isoprenaline was observed. It is suggested that while an i.v. infusion of epinephrine causes a release of platelets from the exchangeable splenic platelet pool, isoprenaline might have the opposite effect on the spleen, thereby causing a decrease of platelets in the peripheral blood.