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Effect of Hyperlipidaemic Diet and Clofibrate Treatment on Rat Erythrocyte Lipids
Author(s) -
PELLINIEMI TARJATERTTU,
VIIKAR JORMA,
NIEMINEN LAURI
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01164.x
Subject(s) - clofibrate , phospholipid , cholesterol , endocrinology , medicine , chemistry , red blood cell , reticulocytosis , biology , biochemistry , membrane , anemia
Lipids of rat plasma and erythrocytes were analysed during hyperlipidaemic diet and clofibrate treatment. The diet increased the plasma cholesterol and phospholipid concentrations after 3 weeks' lipid feeding. Clofibrate in a dose of 200 mg/kg body weight did not inhibit the increase in plasma cholesterol and phospholipid contents, but significantly decreased the concentration of plasma triglycerides. The lipid diet slightly increased the erythrocyte cholesterol and phospholipid concentrations without affecting the red cell morphology or reticulocytosis. After 1 week's treatment, clofibrate in a dose of 200 mg/kg body weight caused a 2‐fold increase in the cholesterol content and a rise in the cholesterol‐phospholipid ratio of red blood cells of rats fed the hyperlipidaemic diet. These results suggest that the erythrocyte cell membrane can increase its cholesterol content and possibly play a role in cholesterol transport.