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Autophagia in Myeloid Precursors
Author(s) -
OBERLING FR.,
LANG J. M.,
JUIF J. G.,
LUCKEL J. C.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01162.x
Subject(s) - vacuole , neutropenia , cytoplasm , autophagy , bone marrow , ultrastructure , myeloid , intramedullary rod , biology , microbiology and biotechnology , pathology , chemistry , immunology , medicine , apoptosis , anatomy , biochemistry , genetics , chemotherapy
Neutropenia is an almost constant feature of Chediak‐Higashi syndrome (CHS). There is evidence for a central mechanism of neutropenia. Ultrastructural studies of the bone marrow from a child with CHS showed marked autophagia phenomena within myeloid precursor cells and mature neutrophils. Autophagic vacuoles were randomly distributed in the cytoplasm of the cells from the granulocytic series and some of them contained giant granules which thus appeared particularly resistant to the autophagic process. The vital cellular damage through endophagocytosis suggests the possibility of intramedullary destruction as an explanation for neutropenia.