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Nonsecretory Myelomatosis without Intracellular Immunoglobulin
Author(s) -
STAVEM PER,
FRøLAND STIG S.,
HAUGEN H. F.,
LISLERUD ARNE
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01159.x
Subject(s) - antibody , bence jones protein , bone marrow , plasma cell , pathology , endoplasmic reticulum , multiple myeloma , surface immunoglobulin , immunoglobulin g , giemsa stain , chemistry , ultrastructure , reticulum , microbiology and biotechnology , biology , immunology , medicine , immunoglobulin light chain , b cell , biochemistry
A patient with multiple myeloma is reported with severe hypogammaglobulinaemia but without monoclonal immunoglobulin (M‐component) in the serum or Bence Jones protein in the urine. In May‐Grünwald‐Giemsa stained bone marrow film 45 % of the cells resembled plasma cells. Marrow immunofluorescent studies showed no increase of immunoglobulin containing cells. Ultrastructural studies showed a large number of cells with a well developed rough endoplasmic reticulum and other morphological features characteristic for plasma cells.