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Fibrin/Fibrinogen Degradation Products (FDP) in Urine and Serum after Prolonged Heavy Exercise
Author(s) -
ARNESEN H.,
ÅKESSON I.,
STRöMME S. B.,
REFSUM H. E.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01151.x
Subject(s) - urine , fibrinogen , fibrin , fibrinolysis , chemistry , urinary system , medicine , albumin , coagulation , endocrinology , immunology
The presence of FDP in the urine, known to be a sensitive indicator of various kidney disorders, was studied in 14 well‐trained men participating in a 70‐km cross‐country ski race. None of the urine samples contained FDP on the day before the race. Immediately after the race, 4 samples contained FDP. High molecular weight FDP were found in 2 of them, whereas 2 others contained low molecular weight products only. 2 days after the race, 1 of these subjects still had FDP in the urine. In addition, 2 newly FDP positives were observed. Serum FDP were slightly elevated in 2 subjects before the race, and in another subject immediately after the race. The presence of urinary FDP did not correlate either with urinary albumin or uromucoid, or with serum FDP. A drop in plasma fibrinogen immediately after the race was noted in all subjects. It is suggested that the present observations may reflect a transient hyperproteolysis (coagulation and fibrinolysis) in the glomerular circulation, including fibrin formation and dissolution, associated with a transient damage of glomerular capillaries.