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Haemostatic and Lipid Abnormalities in Hypothyroidism
Author(s) -
Nordøy Arne,
VikMo Harald,
Berntsen Harald
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01131.x
Subject(s) - partial thromboplastin time , platelet , medicine , endocrinology , phospholipid , thromboplastin , total cholesterol , cholesterol , chemistry , bleeding time , coagulation , platelet aggregation , biochemistry , membrane
10 patients with hypothyroidism were examined before and 3 months after initiation of thyroxin treatment. All patients had high levels of plasma total cholesterol and total phospholipids, and 5 had an additional hypertriglyceridaemia. 1 patient had a prolonged primary bleeding time and all had a prolonged activated partial thromboplastin time and recalcification time in plasma. Platelet factor 3 activity in platelet rich plasma was reduced and total phospholipid and protein concentration in platelets were low. No significant correlation could be established between the observed lipid, protein and haemostatic parameters, and it is suggested that they represent independent phenomena. All abnormalities were corrected by thyroxin replacement.