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Correlations between the Deoxyuridine‐Suppressed Value and Some Conventional Haematological Parameters in Patients with Folate or Vitamin B 12 Deficiency
Author(s) -
Wickramasinghe S. N.,
Saunders J.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb01126.x
Subject(s) - deoxyuridine , vitamin b12 , red cell , vitamin , vitamin b , medicine , endocrinology , chemistry , biochemistry , dna
The correlations between the deoxyuridine‐suppressed value and some conventional haematological parameters (Hb concentration, red cell count, MCV, total white cell count, red cell folate level and serum vitamin B 12 level) have been investigated in 40 patients with megaloblastic haemopoiesis due to folate or vitamin B 12 deficiency. The only statistically significant correlations found were (a) an inverse correlation between the deoxyuridine‐suppressed value and the Hb level or red cell count in both the folate‐ and vitamin B 12 ‐deficient groups and (b) a direct correlation between the deoxyuridine‐suppressed value and MCV in the vitamin B 12 ‐deficient group. The results indicated that the deoxyuridine‐suppressed value was a better index of the magnitude of the disturbance in red cell production induced by folate or vitamin B 12 deficiency than either the red cell folate or serum vitamin B 12 levels.