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Circulating Micromegakaryocytes Signaling Blast Transformation of Chronic Myeloid Leukaemia
Author(s) -
Udomratn T.,
Steinberg M. H.,
Dreiling B. J.,
Lockhard V.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb00333.x
Subject(s) - chronic myeloid leukaemia , blast crisis , megakaryocyte , bone marrow , medicine , pathology , myeloid , dysplasia , immunology , peripheral blood , biology , haematopoiesis , stem cell , genetics
A patient with chronic myeloid leukaemia had numerous micromegakaryocytes in the peripheral blood and bone marrow appearing coincidentally with the onset of blast crisis. These cells were initially confused with lymphocytes because of their size, configuration and scanty cytoplasm. The true identification of these cells can be suspected by careful scrutiny of well prepared Wrights stained preparations and proven electronmicroscopically. Such marked dysplasia of the megakaryocyte series appears to be a poor prognostic sign in chronic myeloid leukaemia.