z-logo
Premium
Extremely Long Duration of Chronic Myeloid Leukaemia with Ph 1 Negative and Ph 1 Positive Bone Marrow Cells
Author(s) -
BrandT L.,
MitelmaN F.,
PananI A.,
LenneR H. C.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb00324.x
Subject(s) - bone marrow , medicine , population , hypoplasia , chronic myeloid leukaemia , myeloid , disease , chromosome , gastroenterology , cancer research , pathology , immunology , biology , genetics , gene , environmental health
A male patient still surviving 17 years after the diagnosis of chronic myeloid leukaemia (CML) is described. A chromosome analysis of the bone marrow 16 years after the diagnosis revealed 84% Ph 1 negative and 16% Ph 1 positive cells, all containing the Y chromosome. The disease has been very sensitive to treatment with busulphan but bone marrow hypoplasia has not been induced. It is probable that in some CML patients with such a double cell population the prognosis may be extraordinarily good and that they run a considerable risk of being overtreated due to a pronounced sensitivity to alkylating drugs. Such rare cases should not serve as arguments for aggressive treatment of CML.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here