Premium
Extremely Long Duration of Chronic Myeloid Leukaemia with Ph 1 Negative and Ph 1 Positive Bone Marrow Cells
Author(s) -
BrandT L.,
MitelmaN F.,
PananI A.,
LenneR H. C.
Publication year - 1976
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1976.tb00324.x
Subject(s) - bone marrow , medicine , population , hypoplasia , chronic myeloid leukaemia , myeloid , disease , chromosome , gastroenterology , cancer research , pathology , immunology , biology , genetics , gene , environmental health
A male patient still surviving 17 years after the diagnosis of chronic myeloid leukaemia (CML) is described. A chromosome analysis of the bone marrow 16 years after the diagnosis revealed 84% Ph 1 negative and 16% Ph 1 positive cells, all containing the Y chromosome. The disease has been very sensitive to treatment with busulphan but bone marrow hypoplasia has not been induced. It is probable that in some CML patients with such a double cell population the prognosis may be extraordinarily good and that they run a considerable risk of being overtreated due to a pronounced sensitivity to alkylating drugs. Such rare cases should not serve as arguments for aggressive treatment of CML.