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A Rare Case of Megaloblastic Anaemia Caused by Disturbances in the Plasma Cobalamin Binding Proteins in a Patient with Hepatocellular Carcinoma
Author(s) -
Nexø Ebba,
Olesen Henrik,
Nørredam Kai,
Schwartz Michael
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb02703.x
Subject(s) - cobalamin , hepatocellular carcinoma , megaloblastic anaemia , medicine , megaloblastic anemia , folic acid , chemistry , endocrinology , pathology , gastroenterology , vitamin b12
A patient with hepatocellular carcinoma, megaloblastic anaemia and increased concentration of serum cobalamin is described. Plasma TC I was increased to 10,000 times the normal concentration, thus explaining the increased concentration of serum cobalamin and a false Schilling test. The increase in plasma TC I in concurrence with undetectable amounts of plasma TC II was a likely explanation for the anaemia. The electron microscopic picture of the hepatocellular carcinoma was in accordance with TC I being produced by the tumour cells.