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Cold‐Haemagglutinin Disease with an Autoantibody Exhibiting Different Specificities at Different Temperatures
Author(s) -
Boccardi Vincenzo,
Girelli Gabriella,
Zappi Pierluigi
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb02426.x
Subject(s) - cold agglutinin , autoantibody , haemolysis , agglutinin , saliva , antibody , chemistry , microbiology and biotechnology , immunology , biology , biochemistry , lectin
A case of chronic cold‐haemagglutinin disease is reported in which an agglutinin apparently carrying two specificities was present. At first, specificity was anti‐not‐I and anti‐I respectively: in the course of time anti‐I was replaced by anti‐A 1 . Both anti‐I and anti‐A 1 could be demonstrated at room temperature only while specificity was anti‐not‐I at 4°C. The antibody displayed haemolytic activity at room temperature and gave stronger reactions when treated biphasically. The same pattern of specificity was apparent in haemolysis tests, i.e. anti‐not‐I in the biphasical reaction 4°C ° 37°C and first anti‐I and later anti‐A 1 at room temperature and at 22°C → 37°C. Anti‐A 1 was not neutralized by A bloodgroup substance of animal origin nor by secretor saliva.