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ULTRASTRUCTURAL STUDY OF ERYTHROPHAGOCYTOSIS IN THE RAT BONE MARROW: II. IRON METABOLISM IN RETICULUM CELLS FOLLOWING RED CELL DIGESTION
Author(s) -
MARTON PER F.
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01096.x
Subject(s) - ferritin , endoplasmic reticulum , bone marrow , ultrastructure , microbiology and biotechnology , reticulum , intracellular , pathology , cell , autophagy , chemistry , biology , biochemistry , medicine , apoptosis
Intracellular transport and storage of iron in bone marrow reticulum cells can be studied in the electron microscope by the recognition of iron macromolecules. Following artificially increased bone marrow erythrophagocytosis ferritin molecules accumulate both in the cell sap and in the lysosomes of erythroclastic reticulum cells. Persistent iron loading transforms lysosomes into siderosomes, after which haemosiderin may be formed by gradual transformation of ferritin. The bone marrow reticulum cell shows evidence suggestive of autophagy, a process which may allow for the transfer of cell sap ferritin into lysosomes, as documented for other types of iron storing cells.