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Allogeneic Marrow Transplantation for the Treatment of Leukaemia
Author(s) -
Alvegård T. A.,
Herzig G. P.,
Graw R. G.
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01084.x
Subject(s) - medicine , bone marrow , immunology , transplantation , bone marrow transplantation , transplantation chimera , allotype , disease , antigen , haematopoiesis , hematopoietic cell , stem cell , biology , genetics
22 HL‐A antigen and mixed leukocyte culture‐matched sibling bone marrow transplants were attempted in patients with acute leukaemia (at the National Cancer Institute) to define the toxicities of four different immunosuppressive regimens, the complications associated with warrow engraftment and antileukaemic effect. 73% (16/22) were engrafted as indicated by a change to donor red blood cells (RBC) type, leukocyte, immunoglobulin allotype or by the speed of marrow repopulation and the occurrence of the Graft Versus Host Disease (GVHD). 12 of 16 (75%) successful engrafted patients developed GVHD. The current published results of clinical bone marrow transplantation from major centers has been reviewed and will be discussed in relationship to current clinical complications associated with bone marrow transplantation.