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Griseofulvin Inhibition of Polymorphonuclear Leucocyte Chemotaxis in Boyden Chambers
Author(s) -
Bandmann Ulf,
Norberg Bo,
Simmingsköld Göran
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01058.x
Subject(s) - griseofulvin , chemotaxis , in vitro , chemistry , microbiology and biotechnology , immunology , pharmacology , biology , medicine , biochemistry , pathology , receptor
Griseofulvin inhibited the chemotaxis of polymorphonuclear leucocytes (PMNs) in vitro in the concentration range 0.1‐1.0 μg/ml, i.e. at concentrations comparable to those obtained in serum during peroral treatment with griseofulvin. It is suggested that PMN chemotaxis is inhibited by griseofulvin interference with the redistribution of cytoplasmic microtubules, which is thought to be essential in the direction‐finding of PMNs during chemotaxis. Furthermore, it is suggested that the griseofulvin inhibition of PMN chemotaxis ‐ together with the previously known pharmacodynamic properties of griseofulvin ‐ may provide the rationale for griseofulvin therapy in PMN‐mediated tissue injury of the gut.