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The in Vitro and in Vivo Evaluation of Tilorone Hydrochloride as a Platelet Aggregation Inhibitor
Author(s) -
Mackenzie R. D.,
Schatzman G. L.
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01055.x
Subject(s) - in vivo , pharmacology , in vitro , platelet aggregation , hydrochloride , chemistry , platelet , medicine , biochemistry , biology , microbiology and biotechnology
Tilorone hydrochloride was tested in vitro for inhibition of platelet aggregation in the ADP, collagen, and epinephrine‐induced platelet aggregation systems. Tilorone did not significantly inhibit the first phase of platelet aggregation induced by ADP, but was a very potent inhibitor of the second phase of platelet aggregation (release reaction) as illustrated by the epinephrine‐induced system. When the compound was given to rats by stomach tube at 100 mg/kg for 2 doses, 24 h apart and blood taken 24 h after the second dose, an inhibition of collagen‐induced platelet aggregation was found. This result is interpreted as inhibiting the release reaction and second phase platelet aggregation.