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In Vitro Inhibition of Endotoxin Induced Platelet Aggregation with Hydrocortisone Sodium Succinate (Solu‐Cortef®)
Author(s) -
Nelson Wm. R.,
Taylor Glen A.
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01053.x
Subject(s) - platelet , chemistry , in vitro , incubation , thrombin , in vivo , platelet rich plasma , platelet aggregation , shock (circulatory) , pharmacology , sodium , optical density , biochemistry , medicine , biology , microbiology and biotechnology , organic chemistry , ophthalmology
Citrated canine platelet rich plasma stimulated with ADP, thrombin, collagen and E. coli endotoxin demonstrated platelet aggregation when measured with Payton aggregometer. Following incubation with hydrocortisone sodium succinate (Solu‐Cortef®) the same platelet rich plasma did not undergo platelet aggregation when stimulated by these agents. Solu‐Cortef added to platelet rich plasma during ATP, thrombin, collagen and endotoxin stimulated platelet aggregation resulted in a reversal of the optical density suggesting deaggregation. These in vitro observations support the beneficial effects observed when steroids are administered in vivo to experimental or clinical shock.