Premium
Lymphosarcoma, Cold Urticaria, IgG 1 Monoclonal Cryoglobulin and Complement Abnormalities
Author(s) -
Hauptmann G.,
Lang J. M.,
North M. L.,
Oberling Fr.,
Mayer G.,
Lachmann P. J.
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01051.x
Subject(s) - cryoglobulin , cryoglobulins , complement (music) , monoclonal antibody , monoclonal , immunology , paraproteinemias , medicine , pathology , virology , antibody , cryoglobulinemia , chemistry , hepatitis c virus , biochemistry , complementation , virus , gene , phenotype
A patient with lymphosarcoma and cold urticaria showed evidence of complement activation by the classical pathway with low levels of the early complement components, normal levels of late acting components, normal functioning of the alternate pathway and reduction of the C1‐inhibitor level. The serum contained an IgG 1 monoclonal cryoglobulin responsible for the complement activation. In vitro tests demonstrated a high capacity of the serum to activate C1.