Premium
Erythrocyte Pyruvate Kinase Activity in Patients with Haematological Malignancies
Author(s) -
Tanphaichitr VoravarnS.,
Eys Jan
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb01049.x
Subject(s) - pyruvate kinase , creatine kinase , red cell , medicine , pyruvate kinase deficiency , enzyme , enzyme assay , endocrinology , immunology , biology , biochemistry , glycolysis , metabolism
Erythrocyte pyruvate kinase (PK) activity was decreased in patients with acute myelomonoblastic leukaemia (AML) and lymphosarcoma cell leukaemia (LSAL) but increased in patients with chronic myelocytic leukaemia (CML). There was no difference in the enzyme activity betwean controls and relatives of patients with AML. PK activity in patients with ALL during complete remission was higher than during untreated and relapsed stages. These data provided evidence that the altered enzyme activity is acquired rather than genetic. There was a positive correlation between PK activity and red cell creatine levels. The red cell creatine was low in patients with AML but high in patients with CML. This suggests that the altered enzyme activity in these patients is at least in part due to red cell age.