Premium
Treatment of Therapy‐Resistant Acute Myeloid Leukaemia with 7 and 8 Cytostatics
Author(s) -
Brincker Hans
Publication year - 1975
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1975.tb00291.x
Subject(s) - medicine , vincristine , prednisolone , cyclophosphamide , methotrexate , regimen , drug , stomach , chemotherapy , myeloid leukaemia , gastroenterology , chronic myeloid leukaemia , myeloid , complication , pharmacology
16 courses of an 8‐drug regimen including daunomycin, vincristine, cytosinearabinoside, thioguanine, methotrexate, cyclophosphamide, prednisolone and hydroxyurea, and 12 courses of a 7‐drug regimen including the same drugs minus hydroxyurea were administered in 16 otherwise therapy‐resistant cases of acute myeloid leukaemia. In spite of a significant and rapid reduction of the leukaemic cell‐mass in all the cases treated, only two brief minimal remissions were obtained. The main toxic effect was myelosuppression. However, the treatment was associated with a high frequency of mucosal ulcerations of the oesophagus and stomach, and it cannot be excluded that the latter complication may be drug‐related.