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Phenotypic Variation in Sickle Cell Trait
Author(s) -
Esan G. J. folayan,
Adesina T. A. O.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00283.x
Subject(s) - nigerians , sickle cell trait , trait , biology , phenotype , globin , medicine , genetics , gene , disease , political science , computer science , law , programming language
The proportion of haemoglobins S and A2 in 244 Nigerians with sickle cell trait was determined. Hb S was found to vary between 20 and 47.5 %, whilst Hb A2 ranged from 1.0 to 4.3 %. The variation of Hb S within families was found to be significantly less than between families. No changes in the level of Hb S occurred in subjects with iron or folate deficiency anaemia following treatment, neither did globin chain synthesis support the presence of alpha thalassaemia. No correlation was found between the proportion of haemoglobins A2 and S.