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Immunoglobulin‐Containing Intranuclear Inclusions in Plasma Cells in a Case of IgG Myeloma
Author(s) -
Stavem Per,
Hovig Torstein,
Frøland Stig,
Skrede Sverre
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00269.x
Subject(s) - antibody , plasma cell , immunofluorescence , electron microscope , pathology , immunoglobulin g , chemistry , hyaline , multiple myeloma , immunoglobulin m , biology , medicine , immunology , physics , optics
A patient with IgG myeloma is reported in whom about 30 % of the plasma cells contained one or more hyaline intranuclear inclusions which were characterized by light, immunofluorescence and electron microscopy. Our results suggest that the intranuclear inclusions consist of immunoglobulin material, with a central core not reacting as immunoglogulin, and often with a surrounding brim of condensed chromatin.