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Platelet Stain Preventing Factor in Serum or Plasma ‐An Early Sign of Leiomyosarcoma?
Author(s) -
Stavem Per,
Berg Kåre,
Flatmark Audun,
Jr Sigvald Refsum
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00259.x
Subject(s) - leiomyosarcoma , stain , platelet , medicine , radiology , pathology , staining
A macromolecular component, platelet stain preventing factor (PSPF), possessing the capacity to prevent staining of platelets in the presence of EDTA, was found in the serum of an apparently healthy person. Two years later, leiomyosarcoma with liver metastases was diagnosed at laparatomy in that particular person. Extract from the patient's leiomyosarcoma exhibited very strong PSPF activity. The observations suggest that PSPF was synthesized in the patient's tumour and that test for PSPF may become a useful tool in early diagnosis of leiomyosarcoma.