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Prevention of Thromboplastin‐Induced Intravascular Coagulation in Rabbits by Warfarin as Monitored by Thrombotest
Author(s) -
Slaastad R. A.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00248.x
Subject(s) - thromboplastin , coagulation , warfarin , fibrin , anticoagulant , platelet , prothrombin time , chemistry , clotting factor , clotting time , medicine , pharmacology , immunology , atrial fibrillation
During sustained DIC in rabbits, the protection by warfarin depended on the anticoagulant effect obtained, as reflected by Thrombotest (TT). Moderate treatment (‘IT below 18 %) was sufficient to prevent decrease in thrombocytes and plasma content of various clotting factors, whereas more intense treatment (TT below 9 %) was required to prevent the Occurrence of soluble fibrin in plasma, as indicated by a positive ethanol gelation test. The present observations suggest that, unless the ethanol test becomes negative, anticoagulant treatment must be considered as insufficient.