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Differences in Morphology and Mitotic Activity between Intra‐ and Extra‐Medullary Erythropoietic Tissue in Chronic Myeloid Leukaemia
Author(s) -
Sjögren U.,
Brandt L.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00244.x
Subject(s) - bone marrow , spleen , mitosis , medullary cavity , pathology , chronic myeloid leukaemia , biology , myeloid , medicine , immunology , microbiology and biotechnology
In 20 untreated patients with CML in the chronic phase the proportion of erythro‐blasts was found to be higher in aspirates from the spleen than in bone marrow smears. The mitotic indices of the erythroblasts were significantly lower, and megalo‐blastic changes more common, in the spleen than in the bone marrow. Although the erythroblasts constitute a considerable proportion of the haemopoietic tissue of the spleen in CML, the relatively low mitotic activity and the megaloblastic changes may indicate an ineffective red cell production in this organ.