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Factor VIII Antigen in the Vessel Walls in Von Willebrand's Disease and Haemophilia A
Author(s) -
Holmberg L.,
Mannucci P. M.,
Turesson I.,
Ruggeri Z. M.,
Nilsson I. M.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00232.x
Subject(s) - von willebrand factor , haemophilia , antigen , haemophilia a , von willebrand disease , medicine , pathology , immunology , surgery , platelet
Biopsy specimens of superficial veins were obtained from 5 patients with von Willebrand's disease and 3 patients with haemophilia A and studied for factor VIII antigen with the aid of a direct immunofluorescent technique. 15 healthy men served as controls. In all the controls a bright specific fluorescence was observed in the intimal layer of the vein, but 3 patients with severe von Willebrand's c'isease lacked the antigenic protein in the intima. The fluorescence was, however, present in one patient with moderately severe von Willebrand's disease and in one patient with an atypical form of the disease, as well as in 3 with classical haemophilia. When protein was found in the vessel wall it was always demonstrable also in the plasma and vice versa. It is assumed that the von Willebrand factor ‐ factor VIII protein exerts an effect on primary haemostasis also locally in the vessel wall.