Premium
Relation between Life Expectancy and Composition of the Bone Marrow at Diagnosis of Chronic Myeloid Leukaemia
Author(s) -
Sjögren U.,
Brandt L.,
Mitelman F.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00223.x
Subject(s) - mitotic index , promyelocyte , bone marrow , chronic myeloid leukaemia , mitosis , blast crisis , medicine , myeloid , pathology , immunology , biology , microbiology and biotechnology
The proportions of myeloblasts (MB), promyelocytes (PMC) and myelocytes (MC) within the granulopoietic precursor pool of the bone marrow and a mitotic index of the precursor cells were determined in 43 patients with chronic myeloid leukaemia (CML) diagnosed in the chronic phase of the disease. There was a negative correlation between the percentages of MB + PMC and the mitotic indices, i.e. large proportions of MB + PMC were associated with low mitotic indices. With increasing proportions of MB + PMC at diagnosis, survival was significantly reduced. Furthermore, only 22 % of patients with MB + PMC above the median value (28 %) associated with a mitotic index below the mean value (1.02 %) survived for more than 2 years whereas 82 % of the patients with a percentage of MB + PMC below the median value combined with a mitotic index above the mean value survived for more than 2 years. It is concluded that the composition and mitotic activity of the granulopoietic precursor pool at diagnosis of CML has a prognostic significance. Successive accumulation of early granulocytic precursors with a low mitotic activity probably occurs in the bone marrow during the chronic phase of CML ending up in the final blast crisis characterized by a heavy predominance of such celis.