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The Effect of Alimentary Hyperlipaemia and Primary Hypertriglyceridaemia on Platelets in Man
Author(s) -
Nordøy Arne,
Strøm Ellen,
Gjesdal Knut
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00218.x
Subject(s) - platelet , medicine , endocrinology , meal , platelet factor 4 , chemistry
30 healthy male subjects were given an isocaloric meal composed mainly of saturated or unsaturated fat. Before and 2 h after the completion of the meal plasma and platelet lipids, platelet factor 3 and platelet factor 4 activity were examined. During alimentary hyperlipaemia a significant increase of platelet triglycerides was seen after both meals. The platelet triglycerides reflected the dietary fatty acids. After the saturated fatty meal an increase of platelet factor 4 activity was present in platelet poor plasma and a decrease in platelet factor 3 availability was present. In 5 subjects with primary hyperlipoproteinaemia all characterized by high levels of plasma triglycerides, the platelet triglycerides and the platelet factor 3 activity and availability were similar to what was found in normal fasting subjects.