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Familial IgA Defects
Author(s) -
Beermann Björn,
Holm Goran
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00214.x
Subject(s) - iga deficiency , daughter , immunoglobulin e , immunoglobulin a , biology , immunology , inheritance (genetic algorithm) , medicine , antibody , genetics , gene , immunoglobulin g , evolutionary biology
Previous reports indicate that deficiency of IgA is sometimes under genetical control. Dominant, recessive and autosomal modes of inheritance have been suggested. This paper describes a family with abnormal levels of IgA in three generations. There was one male with benign monoclonal IgA‐λ‐elevation in the first generation. The daughter and two of her three children (one male and one female) had IgA deficiency. In addition, two of these subjects had subnormal levels of IgE. One of the IgA (and IgE) deficient individuals had chronic urticaria, whereas the other two were healthy.