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The Effect of RA 233 on Platelet Function in vitro and after Administration to Man
Author(s) -
Warlow Charles,
Forman Kathleen,
Ogston D.,
Douglas A. S.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00204.x
Subject(s) - platelet , in vitro , pharmacology , in vivo , drug , oral administration , medicine , adhesion , platelet adhesiveness , platelet aggregation , immunology , chemistry , biology , biochemistry , microbiology and biotechnology , organic chemistry
RA 233 inhibited human platelet adhesion and aggregation in vitro. However, the administration of 3 g daily to human subjects for one week caused no alteration in the same parameters of platelet function. The lack of effect of RA 233 in vivo is likely to be due to inadequate blood levels of the drug being attained by acceptable oral doses and it is, therefore, unlikely that this drug would have any beneficial effect on thrombogenesis.