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Studies on Coagulation and Fibrinolysis in Experimental Pulmonary Embolism in Dogs
Author(s) -
Rø J. S.,
Bergan A.,
Amundsen E.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00201.x
Subject(s) - fibrinolysis , fibrin , fibrinogen , coagulation , platelet , pulmonary embolism , medicine , thrombin , thrombosis , endocrinology , immunology , anesthesia , chemistry
Pulmonary embolism was induced in anaesthetized dogs by injection of autologous blood clot fragments. The short‐term effects (1 h) were studied in 17 dogs and the long‐term effects (4 d) were followed in 7 of them. A slight activation of coagulation and fibrinolysis seemed to occur. The ethanol gelation test was positive for some hours after the embolization, and the levels of platelets and clotting factors I, II/ VII/X, V and VIII decreased moderately. Serum concentration of fibrinogen‐fibrin related antigens increased to a maximum level after 1 h when proteolytic capacity and plasminogen assays were unaffected. Lower levels were revealed, however, after 24 h when fibrinogen‐fibrin related antigen level had largely returned to normal. The same type of fibrinolytic response has previously been experienced after thrombin induced intravascular coagulation. Initially, the level of leucocytes decreased relatively more than that of platelets, as also observed after thrombin infusion. The Thrombotest/Normotest discrepancy which has frequently been found in active thrombosis, did not occur in this study.