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Possible Mechanism of Vinblastine‐Induced Thrombocytosis
Author(s) -
Klener P.,
Donner L.,
Hynčica V.,
ŠAfránková D.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00198.x
Subject(s) - thrombocytosis , megakaryocyte , vinblastine , vinca , platelet , stem cell , bone marrow , medicine , myeloid , haematopoiesis , mechanism (biology) , endocrinology , pharmacology , biology , microbiology and biotechnology , chemotherapy , philosophy , epistemology
Following administration of lower doses of vinca alkaloids a significant thrombocytosis can develop. The authors have attempted to explain the mechanism of this phenomenon. 40 female rats of the Wistar strain were sublethally irradiated from a 60 Co cobalt source. The postradiation depression phase as well as the regeneration phase (depending on intact stem cells) has an approximately parallel course in erythroid, myeloid and megakaryocyte lines. When vinblastine was administered during the period of depression, the platelet count was restored more rapidly and even significant thrombocytosis appeared. The authors suggest that this might be due to increased stem cell differentiation into the megakaryocyte compartment.