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IgG Subclasses: Relationship to Clinical Aspects of Multiple Myeloma and Frequency Distribution among M‐Components
Author(s) -
Schur Peter H.,
Kyle Robert A.,
Bloch Kurt J.,
Hammack William J.,
Rivers Shirley L.,
Sargent Austin,
Ritchie Robert F.,
McIntyre O. Ross,
Moloney William C.,
Wolfson Lynda
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00181.x
Subject(s) - multiple myeloma , immunoglobulin g , myeloma protein , immunology , antibody , medicine
The possible role of IgG subclasses in patients with M‐components or multiple myeloma was investigated. Among 900 patients with monoclonal proteins, the following IgG subclasses were identified: 77 % were IgG 1 ; 14 % were IgG 2 ; 6 % were IgG 3 ; and 3 % were IgG 4 . The IgG of normal sera consists of 64–70 % IgG 1 , 23–28 % IgG 2 , 4–7 % IgG 3 and 3–4 % IgG 4 . IgG 1 M‐components were seen more frequently and IgG 2 less frequently than had been expected. There were 389 patients with documented multiple myeloma assigned to four subgroups based upon IgG sub‐classification of their M‐components. These four groups resembled each other in many respects, but patients with IgG 2 myeloma tended to develop hypercalcaemia and anaemia more frequently than patients with IgG 1 or IgG 4 myeloma; patients with IgG 3 myeloma tended to develop anaemia and had azotaemia more frequently than patients with IgG 1 or IgG 4 myeloma.