Premium
Composition and Mitotic Activity of the Erythropoietic Part of the Bone Marrow in Chronic Myeloid Leukaemia
Author(s) -
Sjögren U.,
Brandt L.
Publication year - 1974
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1974.tb00175.x
Subject(s) - bone marrow , basophilic , chronic myeloid leukaemia , mitosis , erythropoiesis , myeloid , medicine , immunology , anemia , biology , pathology , microbiology and biotechnology
The Hb concentration was successively reduced when leucocytosis increased in 27 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythropoietic cells within the bone marrow was not significantly changed with increasing WBC counts from 20,000–340,000. The development of anaemia was associated with an increase in basophilic erythroblasts within the erythropoietic pool and an augmentation of the mitotic indices of the erythroblasts. Concurrently with the accumulation of early erythroid precursor cells a similar ‘shift to the left’ was observed within the granulopoietic part of the bone marrow. The results indicate that the development of anaemia during the course of CML is not associated with a reduction of erythropoietic tissue. On the contrary, the erythropoietic pool is probably greater in anaemic patients with severe leucocytosis than in non‐anaemic patients with only moderate leucocytosis since the total mass of bone marrow is considerably increased in CML in relapse. It is suggested that the differentiation of early erythroblasts towards more mature erythroid cells becomes progressively blocked during the course of the disease, resulting in an accumulation of basophilic erythroblasts and contributing to the development of anaemia.