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Kinetic Distinction of Two Mechanisms for Platelet Retention
Author(s) -
Cronberg Stig,
Holmberg Lars
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00146.x
Subject(s) - platelet , retention time , chemistry , von willebrand factor , von willebrand disease , medicine , chromatography
The influence of several parameters was investigated using modifications of the platelet retention method of Bowie. The results indicated two mechanisms for platelet retention. In von Willebrand's disease platelets were retained in a random manner by increasing the contact time of the platelets. This process was a slow constant retention which in normal individuals was superseded by the appearance of an aggregating principle that rather suddenly markedly increased the platelet retention. This accelerated retention did not occur in the patients with von Willebrand's disease. It appeared faster in columns of long length but was independent of the rate of flow, the amount of blood passed through and the contact time of the platelets. The accelerating principle was probably identical with or closely related to the von Willebrand factor in plasma.