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The Influence of Haemoglobin on the Fibrinolytic Enzyme System
Author(s) -
Ogston D.,
Herbert R. J.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00145.x
Subject(s) - fibrinolysis , plasmin , chemistry , urokinase , esterase , myoglobin , enzyme , factor xii , biochemistry , inhibitory postsynaptic potential , medicine , endocrinology , coagulation , biology
Haemoglobin, at concentrations above 0.05 mg/ml, inhibited both contact‐induced generation of fibrinolytic activity and that induced by HF co‐factor in glass‐adsorbed plasma; at higher concentrations myoglobin had a similar inhibitory activity. In contrast, cytochrome c inhibited contact‐induced fibrinolysis, but did not influence HF co‐factor‐induced fibrinolysis. HF did not inhibit the fibrinolytic or AGLMe esterase activity of urokinase, and did not influence the caseinolytic or ALMe esterase activity of plasmin. It is concluded that HF exerts its inhibitory effect on the factor XII‐dependent fibrinolytic pathway at a stage between activated HF co‐factor and the activation of plasminogen.