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Coexistence of a Myelo‐ and Lymphoproliferative Disorder
Author(s) -
Louwagie A. C.,
Desmet V. J.,
Berghe H. Den
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00142.x
Subject(s) - haematopoiesis , peripheral blood , pathology , bone marrow , medicine , immunology , biology , stem cell , genetics
A 66‐year‐old man developed generalised lymphadenopathy several years after the onset of anaemia due to an agnogenic myelosclerosis. Cytological and histological examination of the lymph nodes confirmed the diagnosis of a coexisting lymphosarcoma. At that time, the peripheral blood smear still showed a leuco‐erythroblastic picture. The blood volume and iron kinetic data were consistent with myelosclerosis. Chromosomal analysis of the peripheral blood showed numerous extra‐chromosomes with presence of two marker chromosomes belonging to the C‐ and G‐group respectively. A decreased immunoglobulin level and a severe impairment of the in vitro lymphocyte transformation after stimulation with PHA were found. The patient was never treated with the cytostatic drugs neither was he submitted to radiation therapy. Different possibilities for the pathogenesis are considered. A defect of the ultimate progenitor stem cell of the haematopoietic and immunopoietic system is proposed as a possible explanation.