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IgM‐Producing Lymphocytes in Peripheral Nerve in a Patient with Benign Monoclonal Gammopathy
Author(s) -
Forssman Olof,
Björkman Gunnar,
Hollender Anders,
Englund NilsErik
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00137.x
Subject(s) - gammopathy , monoclonal gammopathy , medicine , chlorambucil , peripheral , peripheral nerve , peripheral neuropathy , pathology , biopsy , immunoglobulin m , paraproteinemias , antibody , monoclonal , monoclonal antibody , immunology , immunoglobulin g , chemotherapy , anatomy , endocrinology , diabetes mellitus , cyclophosphamide
This is the first case, hitherto described, of benign essential gammopathy, presenting symptoms and histological evidence of peripheral neuropathy. Furthermore, in no previous case, has a specific localization of immunoglobulin (type IgM) to the areas of nerves involved by the lymphocytes been demonstrated. After six months' treatment with chlorambucil the neurological symptoms disappeared and in a biopsy from the right n saphenus no endoneural lymphocytes or local IgM could be found.