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The Relationship between Red Cell Acetylcholinesterase Activity and Ii Antigenicity in Leukaemia
Author(s) -
Scott G. L.,
Dornhorst Anne,
Rasbridge Marian R.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00122.x
Subject(s) - acetylcholinesterase , antigenicity , red cell , aché , population , cell , medicine , immunology , chemistry , endocrinology , biochemistry , antigen , enzyme , environmental health
Red cell acetylcholinesterase (AChE) activity and Ii antigenicity have been compared in patients with acute leukaemia and myeloproliferative syndromes. In acute leukaemia in relapse increased i agglutinability was found, often associated with low AChE levels, whereas in myeloproliferative syndromes increased i agglutinability was associated with increased AChE activity and increased red cell creatine. These findings are consistent with a young red cell population as similar changes were found in patients with severe haemolytic anaemia. It is proposed that two different mechanisms might be operating to produce increased i agglutinability.