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Red Blood Cell Acetylcholinesterase Activity and Lysis in Various Dyshaemopoietic Disorders
Author(s) -
Stathakis N.,
Papayannis A. G.,
Scliros Ph.,
Gardikas C.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00119.x
Subject(s) - acetylcholinesterase , haemolysis , hemolysis , medicine , red cell , immunology , lysis , myelofibrosis , red blood cell , aché , enzyme , chemistry , bone marrow , biochemistry
144 patients with various dyshaemopoietic disorders were tested for red blood cell acetylcholinesterase (RBC‐AChE) activity and for in vitro lysis in the acidified‐serum test and sucrose haemolysis test. The RBC‐AChE activity was significantly reduced in acute leukaemia, chronic myeloid leukaemia and myelofibrosis. In all other cases the enzyme activity was normal, except in patients with chronic lymphatic leukaemia complicated with autoimmune haemolytic anaemia. The acidified‐serum test was negative in all cases. The sucrose haemolysis test was positive in a significant number of patients, particularly in those with acute leukaemia, chronic myeloid leukaemia and myelofibrosis. The acute leukaemia and myelofibrosis cases with severe anaemia had lower RBC‐AChE activity than those without or with mild anaemia; also cases with positive sucrose lysis test had lower AChE activity than those with negative test.