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The Induction of Chromosome Abnormalities by Melphalan in Rat Bone Marrow Cells
Author(s) -
Wantzin Gunhild Lange,
Jensen Mogens Krogh
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00107.x
Subject(s) - melphalan , bone marrow , chromatid , chromosome , in vivo , biology , medicine , pathology , chemotherapy , genetics , gene
The cytogenetic effect of melphalan was studied in bone marrow cells of Wistar rats in vivo. Melphalan produces structural aberrations of the chromatid and chromosome type, whereas no numerical aberrations were seen. The proportion of abnormal metaphases varied with the period that had elapsed since the administration of melphalan. Repeated large doses of melphalan were not able to produce permanent damage to the chromosome complement.