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Glucose‐6‐Phosphate Dehydrogenase Deficiency and Myelofibrosis
Author(s) -
Selroos Olof,
Vuopio Pekka
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00103.x
Subject(s) - myelofibrosis , haemolysis , glucose 6 phosphate dehydrogenase deficiency , medicine , spleen , red cell , splenectomy , anemia , immunology , bone marrow
A presentation is made of a patient with myelofibrosis and chronic haemolytic anaemia. Known causes of haemolysis in combination with myelofibrosis were excluded. A hereditary red cell glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency was found. The case history is reported, along with the results of haematological investigations in the affected members of the family. Emphasis is laid on the opinion that not only red cell sequestration in the spleen and a PNH‐like syndrome must be taken into account, but also G‐6‐PD deficiency, particularly when haemolytic episodes occur in combination with bacterial infections in patients with myelofibrosis.