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Chronic Lymphocytic Leukaemia in 5 Siblings
Author(s) -
Schweitzer Marjan,
Melief C. J. M.,
Ploem J. E.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00102.x
Subject(s) - immunology , immune system , etiology , sibling , chronic lymphocytic leukemia , childhood leukaemia , medicine , biology , genetics , pathology , leukemia , pediatrics , psychology , developmental psychology
In 5 siblings of a family comprising 7 siblings and 2 half sibs, chronic lymphocytic leukaemia was diagnosed. Since the occurrence of such families strongly suggest that a familial factor may play a role in the aetiology of chronic lymphocytic leukaemia, parameters of the immune system and several genetic markers were determined. In addition electron microscopy and chromosome studies of the lymphocytes were performed. However, so far no clue about the nature of such a familial factor could have been detected.