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Coagulation and Fibrinolysis Factors in Burned Rats
Author(s) -
Rammer Lennart
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00068.x
Subject(s) - fibrinolysis , fibrinogen , fibrin , coagulation , urokinase , platelet , medicine , chemistry , saline , endocrinology , immunology
After a standardized, sublethal, third degree thermal injury in the rat, serial coagulation and fibrinolysis factor determinations were performed. The results showed slight depressions of platelets, fibrinogen, factor V and Normotest values during the first hours after the burn, but previous heparinization did not influence the platelet and fibrinogen values. During the following days a considerable increase in fibrinogen, Normotest values and platelet count was found. Shortly after the burn there was enhanced fibrinolytic activity in plasma, which then gradually declined, and during the following days the lytic activity of euglobulin and plasma on fibrin plates was normal. The plasminogen concentration remained low for several days post‐burn. After 2 and 3 days an increased level of urokinase inhibitors and antiplasmin was found. Plasminogen activators in the lung and kidney 2 days post‐burn, measured histochemically and as the lytic activity of saline extracts on fibrin plates, were normal.