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Bovine Fibrinogen‐Induced Platelet Factor 3 and Acid Phosphatase Availability in Human Platelets
Author(s) -
Kubisz P.,
Suranová J.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00059.x
Subject(s) - fibrinogen , platelet , chemistry , biochemistry , phosphatase , acid phosphatase , extracellular , alkaline phosphatase , enzyme , immunology , biology
On the assumption that, under certain conditions, acid phosphatase may serve as an enzymatic marker of the lipoprotein complex which shows the thromboplastic activity of platelets, the changes in the platelet factor 3 (PF 3) activity after induction by bovine fibrinogen were studied simultaneously with those in acid phosphatases (APh). It has been found that bovine fibrinogen induces not only the aggregation of human platelets and the ADP release, but also the availability of PF 3 and APh. The effect of bovine fibrinogen depends to a certain degree upon its quantity, and the presence of extracellular calcium; it is potentiated by ADP. The inhibitors of the aggregation by bovine fibrinogen inhibit proportionately even the availability of PF 3 and APh. It seems that the mechanisms, by means of which PF 3 and APh become available, depends not only on the release of ADP from the platelets, but above all on the intensity of aggregation.