Premium
Cytogenetic Studies During Remission of Blastic Crisis in a Patient with Chronic Myelocytic Leukaemia
Author(s) -
Srodes C. H.,
Hyde E. F.,
Pan S. F.,
Chervenick P. A.,
Boggs D. R.
Publication year - 1973
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1973.tb00049.x
Subject(s) - blast crisis , clone (java method) , philadelphia chromosome , chromosome , medicine , immunology , biology , cancer research , genetics , leukemia , chromosomal translocation , dna , gene
A patient's clinical course with Phi‐positive chronic myelogenous leukaemia is described. Blastic transformation was associated with a double Ph 1 chromosome and megaloblastosis. During remission, the megaloblastosis disappeared and the cytogenetic pattern reverted to a single Ph 1 chromosome. A second blast crisis occurred terminally with a reappearance of aberrant red cell maturation and a double Ph 1 chromosome and aneuploidy. The possible significance of these observations to the clone theory of blastic crisis evolution is discussed.